Nefropatía de la obesidad

20 de enero de 2021 |
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Nefropatía de la obesidad


La obesidad constituye un factor independiente de riesgo para la aparición y progresión de daño renal y puede causar, por sí misma, insuficiencia renal terminal. La forma más conocida de afectación renal en la obesidad es la glomerulopatía de la obesidad, cuyo dato distintivo es la glomerulomegalia. Este aumento del volumen glomerular se acompaña en ocasiones de lesiones de glomeruloesclerosis segmentaria y focal (GSF). Aunque son varios los mecanismos patogénicos que participan en la glomerulopatía de la obesidad, uno de los más importantes es la hiperfiltración glomerular, característica de los sujetos obesos o con sobrepeso. La coexistencia de otras causas de hiperfiltración, como diabetes o reducción de masa renal, agrava los efectos perjudiciales de la obesidad.

En algunos pacientes puede desarrollarse proteinuria masiva, pero sin que se manifiesten los componentes típicos del síndrome nefrótico (edema, hipoalbuminemia). El tratamiento con inhibidores del sistema renina-angiotensina-aldosterona (SRAA) y la pérdida de peso, bien con dietas hipocalóricas o con cirugía bariátrica, son las únicas alternativas terapéuticas disponibles hoy en día. No obstante, no se han realizado estudios clínicos prospectivos con el tamaño suficiente como para demostrar de manera inequívoca su eficacia y un número significativo de casos desarrolla finalmente insuficiencia renal terminal. Por ello, la identificación de nuevos agentes terapéuticos es una necesidad médica de gran importancia.

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  617. Keravita Pro™ is a dietary supplement created by Benjamin Jones that effectively addresses nail fungus and hair loss, promoting the growth of healthier and thicker nails and hair. The formula is designed to target the underlying causes of these health issues and provide comprehensive treatment. https://keravitapro-web.com

  618. GlucoBerry is one of the biggest all-natural dietary and biggest scientific breakthrough formulas ever in the health industry today. This is all because of its amazing high-quality cutting-edge formula that helps treat high blood sugar levels very naturally and effectively. https://glucoberry-web.com/

  625. Arctic blast is a powerful formula packed with natural ingredients and can treat pain effectively if you’re struggling with chronic pain. You can say goodbye to muscle cramps with this natural pain reliever in less than a minute. It helps with arthritic pain, blood circulation, and joint pain. It gives long-lasting effects that replace the need to go to surgery. https://arcticblast-web.com

  629. PotentStream is designed to address prostate health by targeting the toxic, hard water minerals that can create a dangerous buildup inside your urinary system It’s the only dropper that contains nine powerful natural ingredients that work in perfect synergy to keep your prostate healthy and mineral-free well into old age. https://potentstream-web.com/

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