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El oxígeno está asociado a las condiciones de vida aerobia y representa la fuerza motriz para el mantenimiento del metabolismo y viabilidad celular. Al mismo tiempo, es muy peligroso ya que da lugar a la formación de compuestos intermediarios muy reactivos, conocidos como especies oxigénicas reactivas (ROS) o radicales libres. Los radicales libres se pueden generar tanto endógenamente, en la propia célula, como exógenamente, de aportación externa.
No cabe duda que todos los sistemas biológicos en ambientes oxigenados han desarrollado mecanismos de defensa antioxidante, tanto a nivel fisiológico como bioquímico. Un antioxidante, se define como “cualquier sustancia que presente a bajas concentraciones, cuando se compara con su sustrato oxidable, disminuye significativamente o inhibe la oxidación”. Un buen antioxidante se caracteriza por su alta efectividad, su variabilidad operativa y versatilidad para poder combinarse con una importante variedad de especies radicales libres.
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