El tratamiento del CCRm tras la progresión a una primera línea. El nuevo concepto del tratamiento del continuo de la enfermedad

20 de enero de 2021 |
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El tratamiento del CCRm tras la progresión a una primera línea. El nuevo concepto del tratamiento del continuo de la enfermedad


En la última década hemos asistido a un progreso importante en el tratamiento del cáncer colorrectal metastásico (CCRm) que se ha traducido en una mayor superviviencia de los pacientes y en una mejoría en su calidad de vida. A esto han contribuido diversos factores, destacando los avances en el rescate quirúrgico de la enfermedad oligometastásica, la incorporación de nuevos medicamentos dirigidos (sobre todo antiangiogénicos y monoclonales antiEGFR y recientemente inmunoterápicos) y la mejor selección de pacientes gracias a biomarcadores, como las mutaciones en RAS o BRAF o la inestabillidad de microsatélites (MSI).

Pero aparte de la incorporación de estas nuevas herramientas al arsenal terapéutico, hemos avanzado en el mejor conocimiento de cómo utilizarlas a lo largo de la evolución de la enfermedad de forma que maximicemos el beneficio para el paciente y minimicemos la toxicidad. Se trata del concepto de tratamiento del continuo de la enfermedad.

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