La hemodiafiltración on-line: state of the art.

20 de enero de 2021 |
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La hemodiafiltración on-line: state of the art.


Se ha descrito una elevada mortalidad y morbilidad de causa preferentemente cardiovascular, así como una pobre calidad de vida de los pacientes urémicos en estadio 5 (CKD-5D) en tratamiento con hemodiálisis (HD) convencional. Se han intentado explicar estos resultados, por las características de los enfermos que se incluyen actualmente en los programas de HD, con mayor edad y grado de co-morbilidad (malnutrición, diabetes y enfermedad cardio-vascular). Además, están iniciando HD pacientes procedentes de diálisis peritoneal con una alta co-morbilidad y de trasplante renal, que están inmunodeprimidos y presentan un perfil inflamatorio crónico. Actualmente, no se conoce con precisión cuál es la toxina(s) urémica(s) que se debe depurar, ni cuándo es el momento de iniciar la diálisis, ni qué modalidad de hemodiálisis (HD) es la más adecuada. Por tanto, hay que introducir nuevas modalidades terapéuticas de diálisis, que permitan reducir la alta tasa de morbi-mortalidad cardiovascular en esta población de alto riesgo.

En lo referente a la HD, no se ha establecido aún qué tipo de esquema de diálisis es el idóneo. Existe una amplia controversia sobre cuánto tiempo debe durar y con qué frecuencia hay que realizar la sesión de diálisis. Entre las diferentes estrategias ensayadas para solventar este problema se ha propuesto incrementar el tiempo de duración o la frecuencia de la sesión de diálisis. Estas medidas potencialmente eficaces, aunque aún no plenamente contrastadas, generan problemas logísticos, presentan complicaciones relacionadas con el acceso vascular y en general, no tienen buena aceptación entre los pacientes.

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